UK 14,304 tartrate

Catalog #: 2466
1 Citation Datasheet / COA / SDS

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2466/10
2466/50

UK 14,304 tartrate | CAS No. 70359-46-5 | Adrenergic alpha-2 Receptor Agonists

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Description: α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)

Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline tartrate

Purity: ≥99%

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Product Details

Citations (1)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

UK 14,304 tartrate is a water-soluble form of UK 14,304 (Cat. No. 0425). Full α₂ adrenergic agonist. Centrally active following systemic administration in vivo.

Technical Data

M.Wt:

442.23

Formula:

C₁₁H₁₀BrN₅.C₄H₆O₆

Solubility:

Soluble to 50 mM in water

Purity:

≥99%

Storage:

Desiccate at RT

CAS No:

70359-46-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Glutamatergic and gabaergic ventral BNST neurons differ in their physiological properties and responsiveness to noradrenaline
NZ Gungor, R Yamamoto, D Pare
Neuropsychopharmacology, 2018;0(0):.
UK-14,304, a potent and selective alpha2-gonist for the characterisation of alpha-adrenoceptor subtypes.
Cambridge
Eur.J.Pharmacol., 1981;72:413
Specific [³H]UK-14,304 binding in human cortex occurs at multiple high affinity states with α₂-adrenergic selectivity and different affinities for GTP.
Andorn et al.
Life Sci., 1988;43:1805
Gene targeting - homing in on α₂-adrenoceptor-subtype function.
Macdonald et al.
TiPS, 1997;18:211
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxyDA lesions of the nigrostriatal pathway.
Chopin et al.
J.Pharmacol.Exp.Ther., 1999;288:798

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for UK 14,304 tartrate

The citations listed below are publications that use Tocris products. Selected citations for UK 14,304 tartrate include:

1 Citation: Showing 1 - 1

Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors.
Authors: Harris Et al.
J Neurosci 2018;38:8922

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