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Urocortin (human)

Catalog #: 1604 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1604/1
Urocortin (human)
1 Image
Description: Endogenous CRF agonist

Purity: ≥95%

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Biological Activity

Urocortin (human) is an endogenous CRF agonist. Ki values are 0.4, 0.3 and 0.5 nM for hCRF1, rCRF2α and mCRF2β respectively.

Technical Data

M.Wt:
4696.29
Formula:
C204H337N63O64
Sequence:
DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV

(Modifications: Val-40 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
176591-49-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of the SALK Institute

Background References

  1. Urocortin suppresses endometrial cancer cell migration via CRFR2 and its system components are differentially modulated by estrogen
    GL Owens, KM Lawrence, TR Jackson, EJ Crosbie, BS Sayan, HC Kitchener, PA Townsend
    Cancer Med, 2017;0(0):.
  2. Corticotropin releasing factor receptors and their ligand family.
    Perrin and Vale
    Ann.N.Y.Acad.Sci., 1999;885:312
  3. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression.
    Reul and Holsboer
    Curr.Opin.Pharmacol., 2002;2:23
  4. The neurobiology of urocortin.
    Skelton et al.
    Regul.Pept., 2000;93:85

Product Datasheets

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