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VH 032 amide-alkylC4-amine

Catalog #: 6465 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6465/25
VH 032 amide-alkylC4-amine | CAS No. 2341796-78-7 | Degrader Building Blocks
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Description: VHL ligand with alkyl linker and terminal amine for onward chemistry
Alternative Names: (S,R,S)-AHPC-C4-NH2

Chemical Name: (2S,4R)-1-((S)-2-(5-aminopentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity: ≥95%

Product Details
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

VH 032 amide-alkylC4-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand plus a short alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was VH 032 - linker 3

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
602.62
Formula:
C27H39N5O4S.2HCl
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2341796-78-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Waste disposal-An attractive strategy for cancer therapy.
    Salami et al.
    Science, 2017;355:1163

Product Datasheets

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Preparation of PROTACs
By Sandipan Roy Chowdhury on 05/20/2020
Species: cells

to make PROTACS

Preparation of PROTACs 6465
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