Vialinin A

Biological Activity

Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC₅₀ values are 1.5, 5.9 and 22.3 μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF-α (IC₅₀ = 0.09 nM) from RBL-2H3 mast cells. Displays anticancer activity decreasing viability in human colonic carcinoma cells. Inhibits VEGF-induced growth and proliferation of HUVECs and production of ROS, cytokines and chemokines in vitro. Also inhibits neovasularization in a mouse model.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Cutting edge: Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORgammat.
   Yang J, Xu P, Han L, Guo Z, Wang X, Chen Z, Nie J, Yin S, Piccioni M, Tsun A, Lv L, Ge S, Li B
   J Immunol, 0;194(9):4094-7.
2. Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta.
   Norikura et al.
   J.Agric.Food Chem., 2011;59:6974
3. Vialinin A is a ubiquitin-specific peptidase inhibitor.
   Okada et al.
   Bioorg.Med.Chem.Lett., 2013;23:4328
4. Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells.
   Onose et al.
   Cell Immunol., 2012;279:140
5. Vialinin A, an edible mushroom-derived p-terphenyl antioxidant, prevents VEGF-induced neovascularization in vitro and in vivo.
   Sonowal et al.
   Oxid Med Cell Longev, 2018;:1052102

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