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VU 0071063

Catalog #: 7057 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7057/50
7057/10
VU 0071063 | CAS No. 333415-38-6 | Inward Rectifier Potassium Channel Activators
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Description: Selective activator of SUR1 Kir6.2 channels

Chemical Name: 7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

Purity: ≥98%

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Biological Activity

VU 0071063 is a selective activator of SUR1 Kir6.2 channels and pancreatic β-cell KATP channels (EC50 = 7 μM and 0.3-10.3 μM, respectively). VU 0071063 inhibits insulin secretion in pancreatic β-cells by inducing hyperpolarization of β-cell membranes and reduces voltage-dependent calcium channel activation and Ca2+ influx. VU 0071063 is active in vivo and brain penetrant.

Technical Data

M.Wt:
326.4
Formula:
C18H22N4O2
Solubility:
Soluble to 5 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
333415-38-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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