Home / Inward Rectifier Potassium Channel Blockers / VU 0134992

VU 0134992

Catalog #: 6877
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6877/50
6877/10
VU 0134992 | CAS No. 755002-90-5 | Inward Rectifier Potassium Channel Blockers
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Description: Kir4.1 blocker

Chemical Name: 2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

VU 0134992 is a Kir4.1 potassium channel blocker (IC50 = 0.97 μM). Displays 10-fold selectivity for Kir4.1 over Kir4.1/5.1 concatemeric channels and >30-fold selectivity over Kir1.1, 2.1 and 2.2. Increases urine output and urinary Na+ and K+ excretion in volume-loaded rats.

Technical Data

M.Wt:
411.38
Formula:
C20H31BrN2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
755002-90-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for VU 0134992

The citations listed below are publications that use Tocris products. Selected citations for VU 0134992 include:

2 Citations: Showing 1 - 2

  1. Detection of astrocytic slow oscillatory activity and response to seizurogenic compounds using planar microelectrode array.
    Authors: Naoki Et al.
    Front Neurosci  2023;16:1050150
  2. Induction of Survival of Motor Neuron (SMN) Protein Deficiency in Spinal Astrocytes by Small Interfering RNA as an In Vitro Model of Spinal Muscular Atrophy.
    Authors: Christoph Et al.
    Cells  2022;11

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