VU 0364770
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Description: Positive allosteric modulator of mGlu4 receptors
Chemical Name: N-(3-Chlorophenyl)-2-pyridinecarboxamide
Purity: ≥99%
Biological Activity
VU 0364770 is a positive allosteric modulator at mGlu4 receptors (EC50 = 290 nM in mGlu4-expressing HEK 293 cells). Reverses haloperidol-induced catalepsy in rats; prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Exhibits affinity for MAO-B and MAO-A (Ki values are 0.72 μM and 8.5 μM respectively). Brain penetrant.Technical Data
M.Wt:
232.67
Formula:
C12H9ClN2O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
61350-00-3
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Membrane-bound and soluble forms of an NMDA receptor extracellular domain retain epitopes targeted in auto-immune encephalitis
R Sharma, FH Al-Saleem, RD Puligedda, A Rattelle, DR Lynch, SK Dessain
BMC Biotechnol., 2018;18(1):41. -
The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.
Jones et al.
J.Pharmacol.Exp.Ther., 2012;340:404
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