VU 0365114

Catalog #: 4404 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
4404/10
4404/50

VU 0365114 | CAS No. 1208222-39-2 | mAChR M5 Modulators

1 Image

Description: Positive allosteric modulator of M5 receptors

Chemical Name: 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione

Purity: ≥98%

View All Products for mAChR M5 Modulators

Product Details

Supplemental Products

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

VU 0365114 is a selective positive allosteric modulator of M₅ (EC₅₀ values are 2.7 μM for human M₅, and >30 μM for M₁, M₂, M₃ and M₄ receptors).

Technical Data

M.Wt:

397.35

Formula:

C₂₂H₁₄F₃NO₃

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Purity:

≥98%

Storage:

Store at RT

CAS No:

1208222-39-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Chemical lead optimization of a pan G_q mAChR M₁, M₃, M₅ positive allosteric modulator (PAM) lead. Part I: development of the first highly selective M₅ PAM.
Bridges et al.
Bioorg.Med.Chem.Lett., 2010;20:558
Heterobiaryl and heterobiaryl ether derived M₅ positive allosteric modulators.
Bridges et al.
Bioorg.Med.Chem.Lett., 2010;20:5617

Product Datasheets

COA view current batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for VU 0365114

There are currently no reviews for this product. Be the first to review VU 0365114 and earn rewards!

Have you used VU 0365114?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.