VU 591 hydrochloride
Discontinued Product
Chemical Name: 6-Nitro-2-[(6-nitro-1H-benzimidazol-2-yl)methoxymethyl]-1H-benzimidazole hydrochloride
Purity: ≥99%
Biological Activity
VU 591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50 = 300 nM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentrations up to 10 μM; does not inhibit Kir2.1, Kir2.3 or Kir4.1. Displays similar potency to VU 590 (Cat. No. 3891).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel.
Bhave et al.
Mol.Pharmacol., 2011;79:42
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