VUF 5681 dihydrobromide

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H₃ receptor agonist.
   Kitbunnadaj et al.
   J.Med.Chem., 2004;47:2414
2. The histamine H3 receptor: from gene cloning to H₃ receptor drugs.
   Leurs et al.
   Nat.Rev.Drug Discov., 2005;4:107
3. Constitutive activity of H₃ autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway.
   Moreno-Delgado et al.
   Neuropharmacology, 2006;51:517

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