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VX 702

Catalog #: 3916
2 Citations Datasheet / COA / SDS

Discontinued Product

3916 has been discontinued.
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VX 702 | CAS No. 745833-23-2 | p38 Inhibitors
1 Image
Description: Orally active p38α and p38β inhibitor

Chemical Name: 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Orally active, ATP-competitive inhibitor of p38α MAPK; also inhibits p38β (KD values are 3.7 and 17 nM respectively).

Technical Data

M.Wt:
404.32
Formula:
C19H12F4N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
745833-23-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Phosphoinositide 3-kinase p110? negatively regulates thrombopoietin-mediated platelet activation and thrombus formation
    TA Blair, SF Moore, TG Walsh, JL Hutchinson, TN Durrant, KE Anderson, AW Poole, I Hers
    Cell. Signal., 2018;0(0):.
  2. RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion.

    Blood, 2012;119(26):6255-8.
  3. Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome.
    Din
    Curr.Opin.Investig.Drugs, 2006;7:1020
  4. Selective p38α inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
    Goldstein et al.
    J.Med.Chem., 2010;53:2345
  5. Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis.
    Damjanov et al.
    Arthrit.Rheumat., 2009;60:1232

Product Datasheets

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Citations for VX 702

The citations listed below are publications that use Tocris products. Selected citations for VX 702 include:

2 Citations: Showing 1 - 2

  1. Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions inhuman astrocytes.
    Authors: O'Sullivan Et al.
    Journal of Neuroinflammation  2016;13:189
  2. RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion.
    Authors: Baudet Et al.
    Blood  2012;119:6255

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