W-7 hydrochloride

Catalog #: 0369
16 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
0369/100

W-7 hydrochloride | CAS No. 61714-27-0 | Calcium Binding Protein Modulator Antagonists

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Description: Calmodulin antagonist. Inhibits myosin light chain kinase

Chemical Name: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

Purity: ≥98%

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Product Details

Citations (16)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

W-7 hydrochloride is a calmodulin antagonist. Inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 μM) and myosin light chain kinase (IC₅₀ = 51 μM). Induces shedding of platelet receptors GPVI, GPV and GPIbα.

Technical Data

M.Wt:

377.33

Formula:

C₁₆H₂₁ClN₂O₂S.HCl

Solubility:

Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

61714-27-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Direct interaction of calmodulin antagonists with Ca²⁺/calmodulin-dependent cyclic nucleotide phosphodiesterase.
Itoh and Hidaka
J.Biochem., 1984;96:1721
N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.
Hidaka et al.
Proc.Natl.Acad.Sci.U.S.A., 1981;78:4354
Hydrophobic regions function in calmodulin-enzyme(s) interactions.
Tanaka and Hidaka
J.Biol.Chem., 1980;255:11078
Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W 7), chlorprom. and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine trachea
Asano et al.
J.Pharmacol.Exp.Ther., 1989;251:764

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for W-7 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for W-7 hydrochloride include:

16 Citations: Showing 1 - 10

Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
Authors: Lopez Et al.
Neuron 2022;110:2283
P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of proliferative vitreoretinopathy.
Authors: Schiff Et al.
Commun Biol 2019;2:162
The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
Authors: Haag Et al.
Cell Rep 2018;24:2418
Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease.
Authors: Yanda Et al.
J Biol Chem 2017;292:17897
Voltage Dependence of a Neuromodulator-Activated Ionic Current.
Authors: Gray and Golowasch
Eneuro 2016;3
Protein kinase G-regulated production of H2S governs oxygen sensing.
Authors: Yuan Et al.
Sci Signal 2015;8:ra37
Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
Authors: Araki Et al.
J Neurosci 2015;85:173
Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.
Authors: Bonnefond Et al.
J Biol Chem 2015;20:535
The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin.
Authors: Hou Et al.
Apoptosis 2015;13:e1002233
Dimerisation of the Drosophila odorant coreceptor Orco.
Authors: Mukunda Et al.
Neuron 2014;8:261

Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
Authors: Chang Et al.
Psychopharmacology (Berl) 2013;34:1096

The calcium signaling pathway regulates leydig cell steroidogenesis through a transcriptional cascade involving the nuclear receptor NR4A1 and the steroidogenic acute regulatory protein.
Authors: Abdou Et al.
Endocrinology 2013;154:511

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
Authors: Midkiff Et al.
PLoS One 2011;6:e25395

Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase.
Authors: Dai Et al.
Front Cell Neurosci 2011;213:403

Dihydrotestosterone stimulates aldosterone secretion by H295R human adrenocortical cells.
Authors: Yanes and Romero
Mol Cell Endocrinol 2009;303:50

Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
Authors: Long Et al.
Carcinogenesis 2009;284:8726

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