W-84 dibromide
Chemical Name: Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide
Biological Activity
W-84 dibromide is a stabilizes cholinergic antagonist-receptor complexes by an allosteric effect. Increases the protective effect of atropine against organophosphate poisoning.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Antimuscarinic action of an alkane-bis ammonium compound alone and in combination with (+)-bensetimide.
Mitchelson
Eur.J.Pharmacol., 1975;33:237 -
Equipotent allosteric effect of W84 on [3H]-NMS binding to cardiac muscarinic receptors from guinea-pig, rat and pig.
Mohr et al.
Pharmacol.Toxicol., 1992;70:198 -
Allosteric stabilisation of [3H]-N-methylscopolamine binding in guinea pig myocardium by an antidote against organophosphate intoxication.
Jepsen et al.
Pharmacol.Toxicol., 1988;63:163
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