Home / 5-HT6 Receptor Agonists / WAY 208466 dihydrochloride

WAY 208466 dihydrochloride

Catalog #: 3904
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3904/10
WAY 208466 dihydrochloride | CAS No. 1207064-61-6 | 5-HT6 Receptor Agonists
1 Image
Description: Selective 5-HT6 agonist

Chemical Name: 3-[(-3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine dihydrochloride

Purity: ≥99%

Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

WAY 208466 dihydrochloride is a high affinity, selective 5-HT6 agonist (EC50 = 7.3 nM at the human 5-HT6 receptor). Elevates cortical GABA levels in vivo in rat frontal cortex. Exhibits antidepressant and anxiolytic-like effects.

Technical Data

M.Wt:
420.33
Formula:
C17H18FN3O2S.2HCl
Solubility:
Soluble to 80 mM in water and to 80 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1207064-61-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Serotonin is a key factor for mouse red blood cell survival.
    Amireault P, Bayard E, Launay J, Sibon D, Le Van Kim C, Colin Y, Dy M, Hermine O, Cote F
    PLoS ONE, 2013;8(12):e83010.
  2. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466.
    Schechter et al.
    Neuropsychopharmacol, 2008;33:1323
  3. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats.
    Carr et al.
    Psychopharmacol.(Berl.), 2010;213:49

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for WAY 208466 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for WAY 208466 dihydrochloride include:

1 Citation: Showing 1 - 1

  1. Activation and blockade of basolateral amygdala 5-HT6 receptor produce anxiolytic-like behaviors in an experimental model of Parkinson's disease.
    Authors: Sun Et al.
    Neuropharmacology  2018;137:275

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for WAY 208466 dihydrochloride

There are currently no reviews for this product. Be the first to review WAY 208466 dihydrochloride and earn rewards!

Have you used WAY 208466 dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.