Home / Oxytocin Receptor Agonists / WAY 267464 dihydrochloride

WAY 267464 dihydrochloride

Catalog #: 3933
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3933/10
WAY 267464 dihydrochloride | CAS No. 1432043-31-6 | Oxytocin Receptor Agonists
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Description: Potent non-peptide oxytocin receptor agonist

Chemical Name: N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-4-[(3,5-dihydroxyphenyl)methyl]-1-piperazinecarboxamide dihydrochloride

Purity: ≥97%

Product Details
Citations (5)
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Biological Activity

WAY 267464 dihydrochloride is a potent, selective non-peptide oxytocin receptor (OTR) agonist (Ki = 58.4 nM at human OTR). Exhibits anxiolytic-like effects. May have therapeutic potential for the treatment of psychosis and schizophrenia.

Technical Data

M.Wt:
654.59
Formula:
C32H35N7O4.2HCl
Solubility:
Soluble to 80 mM in DMSO and to 5 mM in water
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
1432043-31-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxyt. receptor agonist.
    Ring et al.
    Neuropharmacology, 2010;58:6

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Citations for WAY 267464 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for WAY 267464 dihydrochloride include:

5 Citations: Showing 1 - 5

  1. Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish.
    Authors: Sandy Et al.
    Nat Commun  2022;13:2573
  2. Physiological and pharmacological evaluation of oxytocin-induced milk ejection in mice.
    Authors: Akihiro Et al.
    Exp Anim  2020;69:345-353
  3. Utilizing Designed Receptors Exclusively Activated by Designer Drug Chemogenetic Tools to Identify Beneficial G Protein-Coupled Receptor Signaling for Fibrosis.
    Authors: Tzu-Ming Et al.
    J Pharmacol Exp Ther  2020;375:357-366
  4. Tph2-/- female mice restore socio-sexual recognition through upregulating ERα and OTR genes in the amygdala.
    Authors: Huo Et al.
    PLoS One  2018;13:e0193395
  5. Biased OXTergic Modulation of Midbrain DA Systems.
    Authors: Xiao Et al.
    Neuron  2017;95:368

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