WAY 316606 hydrochloride
Chemical Name: 5-(Phenylsulfonyl)-N-4-piperidinyl-2-(trifluoromethyl)benzene sulfonamide hydrochloride
Purity: ≥99%
Biological Activity
WAY 316606 hydrochloride is a secreted Frizzled-Related Protein-1 (sFRP-1) inhibitor (IC50 = 0.65 μM); prevents sFRP-1 from interacting with Wnt and thus increases Wnt signaling. Increases total bone area in a murine calvarial organ culture assay.We are aware of a study in PLOS Biology where WAY-316606 was found to stimulate hair follicle growth. Please note that WAY-316606 from Tocris is for laboratory research use only, and that we will only sell to established scientific businesses and institutes.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration
R Ichijo, H Kobayashi, S Yoneda, Y Iizuka, H Kubo, S Matsumura, S Kitano, H Miyachi, T Honda, F Toyoshima
Nat Commun, 2017;8(1):508. -
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: part II.
Moore et al.
Bioorg.Med.Chem., 2010;18:190 -
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides.
Moore et al.
J.Med.Chem., 2009;52:105 -
A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation.
Bodine et al.
Bone, 2009;44:1063
Product Datasheets
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Citation for WAY 316606 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for WAY 316606 hydrochloride include:
1 Citation: Showing 1 - 1
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Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration.
Authors: Ichijo Et al.
Nat Commun 2017;8:508
FAQs
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I have seen the recent news reports that indicate this product can be used to cure baldness. I would like to know how I would place an order or use the product to prevent further hair loss or stimulate hair growth.
I'm sorry for your loss but we will not be able to help you. This product is intended for research use only by trained scientific professionals. It must not under any circumstances be used for human, drug, food, cosmetic, agricultural, domestic or any other unapproved consumer purpose.
This product has not undergone the rigorous testing, regulatory inspections and approvals that would be required for a pharmaceutical grade product. We cannot legally sell these products for personal use.
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