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WIKI4

Catalog #: 4855
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4855/5
4855/25
WIKI4 | CAS No. 838818-26-1 | Tankyrase Inhibitors
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Description: Potent tankyrase inhibitor

Chemical Name: 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

WIKI4 is an inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the ubiquitination and degradation of axin. WIKI4 inhibits expression of β-catenin target genes in cancer cell lines as well as in human embryonic stem cells (ESC).

WIKI4 synthesized to Ancillary Material Grade also available.

Technical Data

M.Wt:
521.59
Formula:
C29H23N5O3S
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
838818-26-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. WIKI4, a novel inhibitor of tankyrase and Wnt/β-catenin signaling.
    James et al.
    PLoS One, 2012;7:e50457

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Citation for WIKI4

The citations listed below are publications that use Tocris products. Selected citations for WIKI4 include:

1 Citation: Showing 1 - 1

  1. Sufu- And Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals.
    Authors: Yung Et al.
    Nat.Commun.  2019;10:4647

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