WQ 1
Chemical Name: 2,3-Dihydro-2-[1-(phenylmethyl)-4-piperidinyl]-4H-1-benzothiopyran-4-one
Purity: ≥98%
Biological Activity
WQ 1 is a high affinity and selective σ1 receptor antagonist (pKi values are 10.28-10.85, 5.81-6.53 and 5.80 at σ1, σ2 and DAT). Displays σ1/σ2 selectivity ratio of 29512. Selectively blocks binge eating without a general inhibition of food intake in rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Investigation of the role of chirality in the interaction with σ receptors and effect on binge eating episode of a potent σ 1 antagonist analogue of spipethiane.
Bello et al.
ACS Chem.Neurosci., 2019;10:3391 -
Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane.
Piergentili et al.
J.Med.Chem., 2010;53:1261
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