WZ 811
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Description: Potent CXCR4 antagonist
Chemical Name: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
Purity: ≥99%
Biological Activity
WZ 811 is a potent chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM).Technical Data
M.Wt:
290.36
Formula:
C18H18N4
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
55778-02-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Discovery of small molecule CXCR4 antagonists.
Zhan et al.
J.Med.Chem., 2007;50:5655 -
Pyridinium N-(2'-azinyl)aminides: regioselective synthesis of N-(2-pyridyl) substituted polyamines.
Reyes et al.
Chem.Inform., 2002;34
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