Home / mAChR M1 Agonists / Xanomeline oxalate

Xanomeline oxalate

Catalog #: 3569
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3569/10
3569/50
Xanomeline oxalate | CAS No. 141064-23-5 | mAChR M1 Agonists
1 Image
Description: Functionally biased muscarinic M4 receptor agonist

Chemical Name: 3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Xanomeline oxalate is a functionally biased muscarinic M4 receptor agonist (EC50 values are 14.1 nM, 30.9 nM, 1700 nM, 1800 nM and 8500 nM at M4, M1, M2, M5 and M3 receptors respectively. Binds with similar affinity to all muscarinic acetylcholine receptors (pKi 6.7-7.7) but displays higher efficacy and efficacy-driven selectivity at M4 receptors. Displays a complex pharmacological profile: reversible and wash-resistant binding, resulting in full agonist activity at M1; delayed wash-resistant partial agonist activity at M2; and delayed wash-resistant full agonist activity at M4. Exhibits antipsychotic activity, and improves cognitive deficits and behavioral disturbances in Alzheimer's disease and schizophrenia.

Technical Data

M.Wt:
371.46
Formula:
C14H23N3OS.C2H2O4
Solubility:
Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
141064-23-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Multiplex single-molecule interaction profiling of DNA-barcoded proteins.
    Gu, Liangcai, Li, Chao, Aach, John, Hill, David E, Vidal, Marc, Church, George M
    Nature, 2014;515(7528):554-7.
  2. Importance and prospects for design of selective muscarinic agonists.
    Jakubik et al.
    Physiol.Res., 2008;57:S39
  3. Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists.
    Heinrich et al.
    Eur.J.Pharmacol., 2009;605:53

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Xanomeline oxalate

The citations listed below are publications that use Tocris products. Selected citations for Xanomeline oxalate include:

2 Citations: Showing 1 - 2

  1. Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex.
    Authors: Pasko Et al.
    Neuron  2020;106:649-661.e4
  2. STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit
    Authors: Tian Et al.
    Scientific Reports  2016;6:36684

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Xanomeline oxalate

There are currently no reviews for this product. Be the first to review Xanomeline oxalate and earn rewards!

Have you used Xanomeline oxalate?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.