Xanthohumol
Chemical Name: (2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
Purity: ≥98%
Biological Activity
Xanthohumol is a p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50 = 50.3 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein.
Sasazawa et al.
ACS Chem.Biol., 2012;7:892 -
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus.
Tabata et al.
Phytochemistry, 1997;46:683 -
Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes.
Inokoshi et al.
J.Antibiot.(Tokyo), 2009;62:51
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Citations for Xanthohumol
The citations listed below are publications that use Tocris products. Selected citations for Xanthohumol include:
2 Citations: Showing 1 - 2
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Antiproliferative and apoptotic effects of xanthohumol in cholangiocarcinoma.
Authors: Muthusamy Et al.
Oncotarget 2017;8:88069-88078
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Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation
Authors: den Brok Et al.
Nature Communications 2016;7:13324
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