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XAP 044

Catalog #: 5248 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5248/10
5248/50
XAP 044 | CAS No. 196928-50-4 | Group III mGluR Antagonists
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Description: Potent and selective mGlu7 antagonist

Chemical Name: 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one

Purity: ≥98%

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Biological Activity

XAP 044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7 deficient mice. Exhibits novel activity by binding to the mGlu7 Venus flytrap domain (VFTD). Exhibits anti-anxiety effects in rodent models. Brain penetrant.

Technical Data

M.Wt:
380.13
Formula:
C15H9IO4
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
196928-50-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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