Y-26763
Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide
Purity: ≥98%
Biological Activity
Y-26763 is a Kir6 (KATP) channel opener and active metabolite of Y-27152. Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state.
Nakajima et al.
J.Pharmacol.Exp.Ther., 1992;261:730 -
Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels
Fukunari et al.
Eur.J.Pharmacol., 1997;323:197 -
Y-26763: ATP-sensitive K+ channel activation and the inhibition of Ins release from human pancreatic β-cells
Cosgrove et al.
Eur.J.Pharmacol., 2004;486:133
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