YE 120

Catalog #: 4457 Datasheet / COA / SDS

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YE 120 | CAS No. 383124-82-1 | Orphan 7-TM Receptor Agonists

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Description: GPR35 agonist

Chemical Name: 2-[3-Cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]propanedinitrile

Purity: ≥98%

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Biological Activity

YE 120 is a GPR35 agonist (EC₅₀ = 32 nM in DMR assays). Also displays partial agonist activity in a β-arrestin translocation assay (EC₅₀ = 10.2 μM).

Technical Data

M.Wt:

330.17

Formula:

C₁₆H₉Cl₂N₃O

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

383124-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Background References

Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists.
Deng et al.
J.Med.Chem., 2011;54:7385

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