Home / Phospholipase Inhibitors / YM 26734

YM 26734

Catalog #: 2522
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2522/10
YM 26734 | CAS No. 144337-18-8 | Phospholipase Inhibitors
1 Image
Description: Secretory phospholipase A2 (sPLA2) inhibitor

Chemical Name: 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone

Purity: ≥95%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

YM 26734 is a competitive inhibitor of secretory phospholipase A2 (sPLA2) that exhibits a broad inhibitory profile to several sPLA2s (IC50 values are 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.

Technical Data

M.Wt:
730.97
Formula:
C45H62O8
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
144337-18-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for YM 26734

The citations listed below are publications that use Tocris products. Selected citations for YM 26734 include:

2 Citations: Showing 1 - 2

  1. Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity.
    Authors: Pernet Et al.
    Nat Commun  2014;5:5105
  2. Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2.
    Authors: Bianca Et al.
    Front Mol Neurosci  2010;161:1835

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for YM 26734

There are currently no reviews for this product. Be the first to review YM 26734 and earn rewards!

Have you used YM 26734?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.