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YM 58483

Catalog #: 3939
10 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3939/10
3939/50
YM 58483 | CAS No. 223499-30-7 | Other Calcium Channel Inhibitors
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Description: Inhibitor of SOCE in non-excitable cells
Alternative Names: Btp2

Chemical Name: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide

Purity: ≥99%

Product Details
Citations (10)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

YM 58483 is a blocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes). Inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM). Displays immuno-modulatory and anti-inflammatory effects; suppresses cytokine production and proliferation of T cells in vitro.

Technical Data

M.Wt:
421.32
Formula:
C15H9F6N5OS
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
223499-30-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes

    J Biol Chem, 2016;0(0):.
  2. BKCa channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells
    M Wakle-Prab, RA Lorca, X Ma, SJ Stamnes, C Amazu, JJ Hsiao, CM Karch, KL Hyrc, ME Wright, SK England
    Proc Natl Acad Sci USA, 2016;113(16):E2335-44.
  3. A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes.
    Ishikawa et al.
    J.Immunol., 2003;170:4441

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Citations for YM 58483

The citations listed below are publications that use Tocris products. Selected citations for YM 58483 include:

10 Citations: Showing 1 - 10

  1. Enhanced Orai1-mediated store-operated Ca2+ channel/calpain signaling contributes to high glucose-induced podocyte injury.
    Authors: Yanfeng Et al.
    J Biol Chem  2022;298:101990
  2. RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
    Authors: Silvia Et al.
    Cell Signal  2021;83:109974
  3. PAR-2-activated secretion by airway gland serous cells: role for CFTR and inhibition by Pseudomonas aeruginosa.
    Authors: Robert J Et al.
    Am J Physiol Lung Cell Mol Physiol  2021;320:L845-L879
  4. TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex.
    Authors: Olivier Et al.
    Cells  2021;11
  5. Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid.
    Authors: Faten Et al.
    Cells  2021;10
  6. Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels.
    Authors: Gregory R Et al.
    Cell Calcium  2020;91:102281
  7. Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex.
    Authors: Jeremy Et al.
    Elife  2020;9
  8. Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.
    Authors: Martin Et al.
    Cell Chem Biol  2017;24:624-634.e3
  9. A store-operated calcium channel inhibitor attenuates collagen-induced arthritis.
    Authors: Gao Et al.
    Br J Pharmacol  2015;172:2991
  10. Potent analgesic effects of a store-operated calcium channel inhibitor.
    Authors: Gao Et al.
    Pain  2013;154:2034

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