Home / Piezo Channel Activators / Yoda 1

Yoda 1

Catalog #: 5586
38 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5586/10
5586/50
Yoda 1 | CAS No. 448947-81-7 | Piezo Channel Activators
1 Image
Description: Piezo1 channel activator

Chemical Name: 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine

Purity: ≥99%

Product Details
Citations (38)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Yoda 1 is a selective activator of mouse and human mechanosensitive channel piezo1. In HEK cells, Yoda 1 slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure. In MDCK cells, Yoda 1 induces Ca2+-dependent chromatin hypercondensation and alters Ca2+-dependent myosin contractility, leading to nuclear shrinkage in cells. In red blood cells from sickle cell anemia (SCA) patients, Yoda 1 increases intracellular Ca2+ and phosphatidylserine exposure, which leads to KCa3.1 channel mediated Ca2+ influx and K+ and water efflux, causing shrinkage of the cells.

Technical Data

M.Wt:
355.27
Formula:
C13H8Cl2N4S2
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
448947-81-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Piezo1 incorporates mechanical force signals to genetic program that governs lymphatic valve development and maintenance
    D Choi, E Park, E Jung, B Cha, S Lee, J Yu, PM Kim, S Lee, YJ Hong, CJ Koh, CW Cho, Y Wu, NL Jeon, AK Wong, L Shin, SR Kumar, I Bermejo-Mo, RS Srinivasan, IT Cho, YK Hong
    JCI Insight, 2019;0(0):.
  2. Spatial Relationship and Functional Relevance of Three Lipid Domain Populations at the Erythrocyte Surface
    L Conrard, A Stommen, AS Cloos, J Steinkühle, R Dimova, H Pollet, D Tyteca
    Cell. Physiol. Biochem., 2018;51(4):1544-1565.
  3. Chemical activation of the mechanotransduction channel Piezo1.
    Syeda et al.
    ELife, 2015;4:e07369
  4. Mechanosensitive meningeal nociception via Piezo channels: Implications for pulsatile pain in migraine?
    Mikhailov et al.
    Neuropharmacology, 2019;149:113

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Yoda 1

The citations listed below are publications that use Tocris products. Selected citations for Yoda 1 include:

38 Citations: Showing 1 - 10

  1. Matrix stiffness induces epithelial-to-mesenchymal transition via Piezo1-regulated calcium flux in prostate cancer cells.
    Authors: Cynthia A Et al.
    iScience  2023;26:106275
  2. Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells.
    Authors: Ping Et al.
    Br J Pharmacol  2023;180:1862-1877
  3. Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi.
    Authors: Yaganoglu Et al.
    Nat Commun  2023;14:4352
  4. Piezo channels contribute to the regulation of myelination in Schwann cells.
    Authors: Yannick Et al.
    Glia  2022;70:2276-2289
  5. Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice.
    Authors: Steven R Et al.
    JCI Insight  2022;7
  6. A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1.
    Authors: Willem-Jan Et al.
    Cell Rep  2022;41:111475
  7. Mechanical Load and Piezo1 Channel Regulated Myosin II Activity in Mouse Lenses.
    Authors: Rupalatha Et al.
    Int J Mol Sci  2022;23
  8. Store-Operated Ca2+ Entry Contributes to Piezo1-Induced Ca2+ Increase in Human Endometrial Stem Cells.
    Authors: Alla Et al.
    Int J Mol Sci  2022;23
  9. Microglial amyloid beta clearance is driven by PIEZO1 channels.
    Authors: Katja M Et al.
    J Neuroinflammation  2022;19:147
  10. Inhibition of chemically and mechanically activated Piezo1 channels as a mechanism for ameliorating atherosclerosis with salvianolic acid B.
    Authors: Yuan Et al.
    Br J Pharmacol  2022;179:3778-3814
  11. Mechanoreceptor Piezo1 Is Downregulated in Multiple Sclerosis Brain and Is Involved in the Maturation and Migration of Oligodendrocytes in vitro.
    Authors: Ilona Et al.
    Front Cell Neurosci  2022;16:914985
  12. Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis.
    Authors: Ting Et al.
    Blood  2022;140:171-183
  13. PIEZO1 mechanoreceptor activation reduces adipogenesis in perivascular adipose tissue preadipocytes.
    Authors: Stephanie W Et al.
    Front Endocrinol (Lausanne)  2022;13:995499
  14. Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels.
    Authors: James Et al.
    Nat Commun  2022;13:600
  15. Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone.
    Authors: Yan Et al.
    Cell Biosci  2022;12:191
  16. Flow-Induced Secretion of Endothelial Heparanase Regulates Cardiac Lipoprotein Lipase and Changes Following Diabetes.
    Authors: James D Et al.
    J Am Heart Assoc  2022;11:e027958
  17. Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation.
    Authors: Udo Et al.
    J Bone Miner Res  2021;36:369-384
  18. Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids.
    Authors: Ophir D Et al.
    Cell Stem Cell  2021;28:1516-1532.e14
  19. Cell fate coordinates mechano-osmotic forces in intestinal crypt formation.
    Authors: Chii Jou Et al.
    Nat Cell Biol  2021;23:733-744
  20. Selective Chemical Activation of Piezo1 in Leukemia Cell Membrane: Single Channel Analysis.
    Authors: Yuri Et al.
    Int J Mol Sci  2021;22
  21. A role of PIEZO1 in iron metabolism in mice and humans.
    Authors: Yu Et al.
    Cell  2021;184:969-982.e13
  22. Mammary mechanobiology - investigating roles for mechanically activated ion channels in lactation and involution.
    Authors: Adler L Et al.
    J Cell Sci  2021;134
  23. TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection.
    Authors: Ping Et al.
    Nat Commun  2021;12:3519
  24. Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-β-catenin.
    Authors: Bo Et al.
    Elife  2020;9
  25. Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation.
    Authors: Erin J Et al.
    Elife  2020;9
  26. Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells.
    Authors: T Simon Et al.
    Elife  2020;9
  27. Inhibition of Piezo1 attenuates demyelination in the central nervous system.
    Authors: Stuart Et al.
    Glia  2020;68:356-375
  28. Piezo1 regulates calcium oscillations and cytokine release from astrocytes.
    Authors: Maria Et al.
    Glia  2020;68:145-160
  29. Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels.
    Authors: Jian Et al.
    Cell Rep  2020;33:108225
  30. Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress.
    Authors: Rodger A Et al.
    J Biol Chem  2020;296:100171
  31. TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.
    Authors: Stephen J Et al.
    J Clin Invest  2020;130:2527-2541
  32. Piezo1-Mediated Ca2+ Activities Regulate Brain Vascular Pathfinding during Development.
    Authors: Qi Et al.
    Neuron  2020;108:180-192.e5
  33. Mammary mechanobiology: Investigating roles for mechanically-activated ion channels in lactation and involution.
    Authors: Adler L Et al.
    J Cell Sci  2020;
  34. Agonist-induced Piezo1 activation suppresses migration of transformed fibroblasts.
    Authors: Chubinskiy-Nadezhdin Et al.
    Biochem Biophys Res Commun.  2019;514:173
  35. Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis.
    Authors: Romac Et al.
    Nat Commun  2018;9:1715
  36. Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.
    Authors: Tsuchiya
    Nat Commun  2018;9(1):2049
  37. Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation.
    Authors: Dela Paz
    Biochem Biophys Res Commun  2018;497(1):220
  38. Evidence for shear-mediated Ca2+ entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line.
    Authors: Ilkan Et al.
    J Biol Chem  2017;292:9204

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Yoda 1

There are currently no reviews for this product. Be the first to review Yoda 1 and earn rewards!

Have you used Yoda 1?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.