Z-DEVD-FMK Caspase-3 Inhibitor
Purity: ≥95%
Biological Activity
Z-DEVD-FMK Caspase-3 Inhibitor is a cell-permeable, irreversible inhibitor of caspase-3/CPP32. It inhibits tumor cell apoptosis. In vivo, it has a neuroprotective effect in rat hippocampus following seizures. It also significantly reduces post-traumatic apoptosis, and improved neurological recovery, before and after induced traumatic brain injury in rat.Technical Data
(Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = DL-Asp(OMe)-fluoromethylketone)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line.
Brocksted et al.
J.Biol.Chem., 1998;273:28057 -
Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures.
Henshall et al.
J.Neurochem., 2000;74:1215 -
Apoptosis of NG108-15 cells induced by Bupren. hydrochloride occurs via the caspase-3 pathway.
Kugawa et al.
Biol.Pharm.Bull., 2000;23:930
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