Z-Guggulsterone
Chemical Name: (Z)-Pregna-4,17(20)-diene-3,16-dione
Purity: ≥98%
Biological Activity
Z-Guggulsterone is a broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo. More active isomer of guggulsterone (Cat. No. 2013).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate-dependent activation of c-Jun NH2-terminal kinase.
Singh et al.
Cancer Res., 2007;67:7439 -
z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo.
Xiao and Singh
Mol.Cancer Ther., 2008;7:171
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Citations for Z-Guggulsterone
The citations listed below are publications that use Tocris products. Selected citations for Z-Guggulsterone include:
2 Citations: Showing 1 - 2
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Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation.
Authors: Michael S Et al.
Cell Host Microbe 2021;29:988-1001.e6
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C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties.
Authors: Ng Et al.
Oncotarget 2016;7:24005
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