Zatebradine hydrochloride
Chemical Name: 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
Purity: ≥98%
Biological Activity
Zatebradine hydrochloride is a bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current If (HCN channel) in sinoatrial node cells (EC50 = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC50 of 13.4 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Use- and frequency-dependent blockade by UL-FS 49 of the if pacemaker current in sheep cardiac Purkinje fibres.
Van Bogaert et al.
Eur.J.Pharmacol., 1990;187:241 -
Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors.
Goethals et al.
Circulation, 1993;88:2389 -
Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current.
Romanelli et al.
Bioorg.Med.Chem., 2005;13:1211
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Citation for Zatebradine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Zatebradine hydrochloride include:
1 Citation: Showing 1 - 1
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Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation.
Authors: Bender Et al.
J Neurosci 2007;27:4697
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