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ZD 7114 hydrochloride

Catalog #: 0930
2 Citations Datasheet / COA / SDS

Discontinued Product

0930 has been discontinued.
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ZD 7114 hydrochloride | CAS No. 129689-28-7 | Adrenergic beta-3 Receptor Agonists
1 Image
Description: β3 agonist
Alternative Names: ICI D7114

Chemical Name: (S)-4-[2-Hydroxy-3-phenoxypropylaminoethoxy]-N-(2-methoxyethyl)phenoxyacetamide hydrochloride

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

ZD 7114 hydrochloride is a β3-adrenoceptor agonist.

Active Metabolite also available.

Technical Data

M.Wt:
454.95
Formula:
C22H30N2O6.HCl
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
129689-28-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Other Product-Specific Information:

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Evaluation of ICI D7114, a putative stimulant of brown adipocytes, on histamine-contracted guinea-pig ileum.
    Growcott et al.
    Br.J.Pharmacol., 1993;109:1212
  3. Effects of ZD7114, a selective β3-adrenoceptor agonist, on neuroendocrine mechanisms controlling energy balance.
    Savontaus et al.
    Eur.J.Pharmacol., 1998;347:265
  4. β3-Adrenergic agonists.
    How
    Drugs Future, 1993;18:529

Product Datasheets

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
SDS
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Citations for ZD 7114 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for ZD 7114 hydrochloride include:

2 Citations: Showing 1 - 2

  1. Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat.
    Authors: Suárez Et al.
    Dis Model Mech  2014;7:129
  2. Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
    Authors: Baker Et al.
    FASEB J  2011;25:4486

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