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ZD 7155 hydrochloride

Catalog #: 1211
2 Citations Datasheet / COA / SDS
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1211/10
1211/50
ZD 7155 hydrochloride | CAS No. 146709-78-6 | Angiotensin AT1 Receptor Antagonists
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Description: Selective non-peptide AT1 antagonist

Chemical Name: 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. Displaces [125I]-angiotensin II binding with an IC50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT1 antagonist, losartan.

Technical Data

M.Wt:
474.99
Formula:
C26H26N6O.HCl
Solubility:
Soluble to 10 mM in water with gentle warming
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
146709-78-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Zeneca ZD7155: a novel, potent and orally-effective angiotensin II receptor antagonist.
    Oldham et al.
    Br.J.Pharmacol., 1993;109:P136
  3. Endogenous angiotensin II and the reflex response to stimulation of cardiopulmonary serotonin 5HT3 receptors.
    Veelken et al.
    Br.J.Pharmacol., 1998;125:1761
  4. Comparative cardiovascular effects of the angiotensin II type 1 receptor antagonists ZD 7155 and los. in the rat.
    Junggren et al.
    J.Pharm.Pharmacol., 1996;48:829

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Citations for ZD 7155 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for ZD 7155 hydrochloride include:

2 Citations: Showing 1 - 2

  1. Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress.
    Authors: Nostramo Et al.
    Proc Natl Acad Sci U S A  2012;215:291
  2. Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect.
    Authors: Leite-Moreira Et al.
    Br J Pharmacol  2006;147:690

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