Zinterol hydrochloride

Name: Zinterol hydrochloride
Brand: Tocris Bioscience
SKU: 1051
Price: 238 USD

Catalog #: 1051
4 Citations Datasheet / COA / SDS

Discontinued Product

1051 has been discontinued.

View all Adrenergic beta-2 Receptor Agonists products.

Zinterol hydrochloride | CAS No. 38241-28-0 | Adrenergic beta-2 Receptor Agonists

1 Image

Description: Selective β2 agonist

Alternative Names: MJ 9184

Chemical Name: N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamide hydrochloride

Purity: ≥98%

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Product Details

Citations (4)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Zinterol hydrochloride is a potent and selective β₂-adrenoceptor agonist (pK_B values are 8.3 and < 5.7 for β₂ and β₁ receptors respectively, as measured in human artery).

Technical Data

M.Wt:

414.95

Formula:

C₁₉H₂₆N₂O₄S.HCl

Solubility:

Soluble to 5 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

38241-28-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Beta-2 adrenergic activation of L-type Ca²⁺ current in cardiac myocytes.
Arvydas Skeberdis et al.
J.Pharmacol.Exp.Ther., 1997;283:452
Four β-adrenoceptor subtypes in the mammalian heart.
Kauman
TiPS, 1997;18:70
Agonist effects of zinterol at the mouse and human β3-adrenoceptor.
Hutchinson et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2006;373:158

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Zinterol hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Zinterol hydrochloride include:

4 Citations: Showing 1 - 4

ADRB2 polymorphism Arg16Gly modifies the natural outcome of heart failure and dictates therapeutic response to β-blockers in patients with heart failure.
Authors: Huang Et al.
Cell Discov 2018;4:57
Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte.
Authors: Macdougall Et al.
J Mol Cell Cardiol 2012;52:388
Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.
Authors: Schutsky Et al.
J Neurosci 2011;31:14172
A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice.
Authors: Eckle Et al.
J Am Coll Cardiol 2008;118:3301

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