ZXH 3-26
Chemical Name: Methyl (6S)-4-(4-chlorophenyl)-2-[[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]carbonyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate
Biological Activity
ZXH 3-26 is a potent and selective BRD4 Degrader (PROTAC®) (DC50 ~ 5 nM). Exhibits no significant degradation of BRD2 and BRD3. Whole proteome mass spectometry shows significant downregulation of BRD4 only. Active intracellularly.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
-
Plasticity in binding confers selectivity in ligand-induced protein degradation.
Nowak et al.
Nat.Chem.Biol., 2018;14:706
Product Datasheets
Citation for ZXH 3-26
The citations listed below are publications that use Tocris products. Selected citations for ZXH 3-26 include:
1 Citation: Showing 1 - 1
-
Engineered PROTAC-CID systems for mammalian inducible gene regulation.
Authors: Ma Et al.
J Am Chem Soc 2023;145:1593
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for ZXH 3-26
There are currently no reviews for this product. Be the first to review ZXH 3-26 and earn rewards!
Have you used ZXH 3-26?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image