ZXH 3-26

Discontinued Product

6713 has been discontinued.
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ZXH 3-26 | CAS No. 2243076-67-5 | Active Degraders
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Description: Potent and selective BRD4 Degrader (PROTAC®)

Chemical Name: Methyl (6S)-4-(4-chlorophenyl)-2-[[[5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentyl]amino]carbonyl]-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetate

Product Details
Citations (1)
Reviews

Biological Activity

ZXH 3-26 is a potent and selective BRD4 Degrader (PROTAC®) (DC50 ~ 5 nM). Exhibits no significant degradation of BRD2 and BRD3. Whole proteome mass spectometry shows significant downregulation of BRD4 only. Active intracellularly.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

Formula:
C38H37ClN8O7S
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
2243076-67-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Background References

  1. Plasticity in binding confers selectivity in ligand-induced protein degradation.
    Nowak et al.
    Nat.Chem.Biol., 2018;14:706

Product Datasheets

Reconstitution Calculator

Citation for ZXH 3-26

The citations listed below are publications that use Tocris products. Selected citations for ZXH 3-26 include:

1 Citation: Showing 1 - 1

  1. Engineered PROTAC-CID systems for mammalian inducible gene regulation.
    Authors: Ma Et al.
    J Am Chem Soc  2023;145:1593

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