Carbonic Anhydrases
Carbonic anhydrases catalyze the reversible reaction of CO2 + H2O = HCO3- + H+, which is fundamental to many processes such as respiration, renal tubular acidification and bone resorption. Human members of the CAs are secreted (CA6), membrane-bound (CA4, 9 to 12 and 14), cytosolic (CA1 to 3, 7, 8 and 13) or mitochondrial (CA5A and 5B). Some CAs may serve as markers for tumors and hypoxia. A subset of CAs lack CA activity due to point mutations but retain esterase function.
- Carbonic Anhydrase I/CA1
- Carbonic Anhydrase II/CA2
- Carbonic Anhydrase III/CA3
- Carbonic Anhydrase IV/CA4
- Carbonic Anhydrase VA/CA5A
- Carbonic Anhydrase VA/VB (CA5A/5B)
- Carbonic Anhydrase VB/CA5B
- Carbonic Anhydrase VI
- Carbonic Anhydrase VII/CA7
- Carbonic Anhydrase VIII/CA8
- Carbonic Anhydrase IX/CA9
- Carbonic Anhydrase X/CA10
- Carbonic Anhydrase XII/CA12
- Carbonic Anhydrase XIII/CA13
- Carbonic Anhydrase XIV/CA14