Kynureninase: Products
Kynureninase (KYNU) catalyzes the hydrolytic cleavage of the amino acids L-kynurenine and L-3-hydroxykynurenine to give either anthranilic acid or 3-hydroxyanthranilic acid and alanine. KYNU degrades dietary tryptophan in the liver and is involved in the de novo biosynthesis of NAD+. In immune system cells, such as macrophages and microglia, KYNU catalyzes inflammatory quinolinic acid (QA) production, which may cause neuronal damage in AIDS-related dementia complex, Alzheimer's, stroke, epilepsy, and Huntington's disease.
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