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Recombinant Human L-Selectin/CD62L Protein, CF

Catalog #: ADP2
3 Citations Datasheet / COA / SDS
Newer Version Available: 728-LS
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Discontinued Product

ADP2 has been discontinued and is replaced by 728-LS. 11169-LS. 11374-LS.

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Citations (3)
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Summary Product Datasheets Carrier Free Reconstitution Calculator Background Related Research Areas

Recombinant Human L-Selectin/CD62L Protein, CF Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Bioassay data are not available.
Source
Chinese Hamster Ovary cell line, CHO-derived human L-Selectin/CD62L protein
Trp39-Asn332
Accession #
P14151
Predicted Molecular Mass
33 kDa
SDS-PAGE
50-70 kDa

Product Datasheets

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ADP2

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

ADP2

Formulation Lyophilized from a 0.2 μm filtered solution in PBS containing Calcium and Magnesium with Sorbitol.
Reconstitution Reconstitute at 0.2 mg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Background: L-Selectin/CD62L

Human L-Selectin (Leukocyte Selectin, LAM-1, LECAM-1, LECCAM-1, TQ1, Leu-8, MEL-14 antigen, DREG, lymph node homing receptor, CD62L), a member of the Selectin family, is a cell surface glycoprotein expressed constitutively on a wide variety of leukocytes. Two forms of L-Selectin have been reported, apparently arising as a result of post-translational modifications. The lymphocyte form shows an apparent molecular weight of 74 kDa, while the neutrophil form is 90-100 kDa. L‑Selectin plays a role in the migration of lymphocytes into peripheral lymph nodes and sites of chronic inflammation, and of neutrophils into acute inflammatory sites. Acting in cooperation with P-Selectin and E-Selectin, L-Selectin mediates the initial interaction of circulating leukocytes with endothelial cells that produces a characteristic ‘rolling' of the leukocytes on the endothelium. This initial interaction is followed by a stronger interaction involving ICAM-1 and VCAM-1, that leads eventually to extravasation of the white blood cell through the blood vessel wall into the extracellular matrix tissue. ELISA techniques have shown that detectable levels of soluble L-Selectin are present in the biological fluids of apparently normal individuals. Furthermore, a number of studies have reported that levels of L-Selectin may be elevated or lowered in subjects with a variety of pathological conditions.

Entrez Gene IDs
6402 (Human); 20343 (Mouse); 29259 (Rat); 102142895 (Cynomolgus Monkey)
Alternate Names
CD62L antigen; CD62L; gp90-MEL; hLHRc; LAM1; LAM-1; LAM1LECAM1; LECAM1; LEU8; Leu-8; Leukocyte adhesion molecule 1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LNHR; LNHRTQ1; LSEL; L-Selectin; LYAM1; Lyam-1; LYAM1CD62 antigen-like family member L; Lymph node homing receptor; lymphocyte adhesion molecule 1; pln homing receptor; PLNHR; selectin L; SELL; TQ1

Citations for Recombinant Human L-Selectin/CD62L Protein, CF

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion.
    Authors: Jang M, Kim Y, Bae E, Oh T, Choi H, Lee J, Oh H, Lee S
    Molecules, 2014-12-04;19(12):20340-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Regulation of leukocyte recruitment by the long pentraxin PTX3.
    Authors: Deban L, Russo RC, Sironi M, Moalli F, Scanziani M, Zambelli V, Cuccovillo I, Bastone A, Gobbi M, Valentino S, Doni A, Garlanda C, Danese S, Salvatori G, Sassano M, Evangelista V, Rossi B, Zenaro E, Constantin G, Laudanna C, Bottazzi B, Mantovani A
    Nat. Immunol., 2010-03-07;11(4):328-34.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Binding Assay
  3. Synthetic glycoprotein mimics inhibit L-selectin-mediated rolling and promote L-selectin shedding.
    Authors: Mowery P, Yang ZQ, Gordon EJ, Dwir O, Spencer AG, Alon R, Kiessling LL
    Chem. Biol., 2004-05-01;11(5):725-32.
    Applications: Western Blot

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