Beclin 1/ATG6: Products

Beclin1 (Bcl-2 interacting coiled-coil protein; also know as ATG6) is a 60 kDa member of the Beclin family of proteins. It is part of a lipid-kinase complex that includes UVRAG and PI3 and induces autophagy; in the presence of Bcl-2, autophagy is repressed. Beclin1 is widely expressed but abundantly found in mammary epithelium, glia and neurons.

Human Beclin1 is 450 amino acids (aa) in length and contains a Bcl-2 binding domain (aa 88-150), a nuclear export signal motif (aa 180-189), a coiled-coil region (aa 142-270), and an evolutionary conserved domain (aa 244-337). There is one potential alternate start site at Met88. Over aa 12-239, human Beclin1 is 98% aa identical to mouse Beclin1.