BID: Products
BID is a member of the Bcl-2 family of proteins that regulates outer mitochondrial membrane permeability. BID is a proapoptotic member that causes Cytochrome c to be released from the mitochondrial intermembrane space into the cytosol. In healthy cells, BID is cytosolic. In response to Fas Ligand or TNF-alpha, BID is cleaved by Caspase-8 and then relocates to the mitochondrial outer membrane.
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