Caspase-7: Products
Caspase-7, also known as CMH-1, ICE-LAP3, and Mch3, is a 32 kDa member of the peptidase C14A/IL-1 beta-converting family of enzymes. It is widely expressed, except in the brain and is best known as an executioner caspase of the apoptotic cascade. Caspase-7 cleaves multiple substrates, including PARP, Pro-Caspase-6, Gas2, and Calpstatin.
Pro-Caspase-7 undergoes proteolytic cleavage to generate a propeptide, a p20, and a p12 subunit. The p20 and p12 subunits noncovalently heterodimerize, and subsequently associate with another p20-p12 heterodimer to form an active antiparallel homodimer. p20 may be additionally processed to generate p18, while p12 may be additionally processed to generate p11. Caspase-7 can be cleaved by multiple proteases including Caspases-1, -3, -8, and -10, Granzyme B, Calpain-1, and Caspase-7 itself. Caspase-7 is found in both the cytosol and nucleus.
Products:
Multi Brand Search Results for "Caspase-7"
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Bio-Techne BrandProduct Category
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Novus Biologicals provides the life science community with high-performing antibodies to over 20,000 unique targets. These antibodies are available conjugated to multiple fluorophores and tested in numerous assays and species. read more
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Tocris Bioscience is the leading supplier of novel, exclusive small molecules and peptides for life science research. read more
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ProteinSimple develops and manufactures proprietary, fully automated systems for protein analysis. read more