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CNTFR alpha: Products
The high-affinity CNTF receptor complex, which mediates the biological action of CNTF, contains the ligand-binding alpha subunit (CNTFR alpha) and two signal-transducing proteins, LIFR beta and gp130. Whereas LIFR beta and gp130 are widely expressed in many cell types, the expression of CNTFR alpha is restricted to the central and peripheral nervous systems. cDNAs encoding CNTFR alpha isolated from both human and rat share 96% amino acid sequence identity.
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