A short description of Butyrophilin proteins produced by R&D Systems. These B7-related proteins may be checkpoint targets.
Recorded December 22, 2017
Blog
Neuroscience Research Review: Neuronal EphB1 Activates a Neuroprotective Astrocyte Phenotype
星期五, 十二月 15, 2017 - 08:36
In the central nervous system (CNS), glia are key for maintaining tissue homeostasis. They function to support numerous processes including neurogenesis and neuronal survival, neural transmission, and immune surveillance. They also play a role in the initiation and progression of neuroinflammation and neurodegenerative disease. Astrocytes, the most abundant glial cell in the CNS, become activated in response to many insults, such as trauma, stroke, or neurodegenerative disease.1 Astrogliosis appears to be a complicated process as research is showing that the phenotype of reactive astrocytes may be defined by...
20 Years and Getting Stronger – The Ins and Outs of SUMOylation
星期二, 十二月 12, 2017 - 16:35
Posttranslational modification with Small Ubiquitin-related Modifier (SUMO) proteins is now established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macromolecular assembly and protein homeostasis, trafficking and signal transduction are subject to reversible sumoylation. It is hence not surprising that disease links are beginning to emerge and that interference with sumoylation is being considered for intervention. In this webinar, Dr. Frauke Melchior provides an overview of fundamental mechanisms and highlight recent developments in the analysis and physiology of sumoylation.
Click...
RNAScope® Technology Hits 1000 Publications
星期三, 十二月 6, 2017 - 07:49
Bio-Techne’s RNAScope® Technology Hits 1000 Publications!
Bio-Techne is celebrating an exciting milestone for our RNAScope® assays from the Advanced Cell Diagnostics brand: 1000 publications citing the use of RNAScope® in situ hybridization (ISH) technology! We have announced this milestone in a press release on November 28, 2017.
With 400 of these publications in 2017 alone, this surge includes a notable increase in the use of the RNAScope technology in the pharmaceutical and biotechnology industries. This increase highlights awareness of the robust, sensitive, and specific ISH assay by...
Intestinal Lamina Propria Cell Markers
星期一, 十二月 4, 2017 - 16:31
R&D Systems Cell Marker Pages: The Easiest Way to Plan Your Next Experiment
One of the challenges of moving into a new research field or expanding your current field of study is determining the best markers to identify the cells you want. R&D Systems has been providing researchers with reliable tools for defining cell populations for over 30 years. Now we’ve added new Cell Marker Tools for Mucosal Immunity, Atherosclerosis, and Asthma on our website!
Each...
Quarterly Protein Product and Data Update: Edition #3
星期一, 十二月 4, 2017 - 12:26
New Products
GFRAL: The Receptor that Mediates the Metabolic Function of GDF-15 is Identified
Several high-profile papers have recently identified GFRAL as a receptor mediating GDF-15 effects on obesity and insulin resistance. R&D Systems’ new Recombinant Human GFRAL binds GDF-15 with an ED50 in the sub ng/mL range....
Several high-profile papers have recently identified GFRAL as a receptor mediating GDF-15 effects on obesity and insulin resistance. R&D Systems’ new Recombinant Human GFRAL binds GDF-15 with an ED50 in the sub ng/mL range....
Stem Cells in the News - December 2017
星期一, 十二月 4, 2017 - 12:12
We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.
Science Daily
A team of researchers at Fred Hutchinson Cancer Research Center have identified a single, specific subset of adult stem cells that are...
RAS Oncoproteins: Therapeutic Vulnerabilities
星期五, 十二月 1, 2017 - 14:05
Adrienne Cox, Ph.D. Associate Professor, UNC Chapel Hill
The three human RAS↗ genes (HRAS↗, KRAS↗ and NRAS↗) encode four highly related RAS small GTPases↗ (HRAS, KRAS4A, KRAS4B and NRAS). RAS proteins function as GDP-GTP regulated binary on-off switches that regulate diverse cytoplasmic signaling networks. In cancer and developmental disorders (RASopathies), mutationally activated RAS proteins drive aberrant signal transduction. RAS proteins are also the founding...
How to Keep Calm and Monitor Cell Stress, Death, and Behavior
星期二, 十一月 21, 2017 - 14:57
Measuring and monitoring cell health, stress, and behavior is a necessary part of using 2D and 3D cell culture models. This can be done qualitatively through microscopic assessment of cell structure, morphology, and confluency. Quantitative assessment of cell stress, death, and behavior is often needed when using 2D or 3D cell cultures for drug discovery, drug screening, and disease modeling. With the acquisition of Trevigen, Bio-Techne now has an extensive portfolio and unmatched expertise in assays and reagents for measuring cellular proliferation, viability, stress, DNA damage, and apoptosis. This blog showcases our expertise by highlighting the various resources and tools available through Bio-Techne.
...Bio-Techne Go Everywhere Travel Grant - October Recipient Selected!
星期五, 十一月 17, 2017 - 14:33
October 2017 Go Everywhere with Bio-Techne Travel Grant Awarded to Post-Doc from University of Tampere!
Bio-Techne launched its Go Everywhere Travel Grant Program which awards $1000 USD (or equivalent) to 1 researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.
The recipient of the October 2017 grant is Krista Rantanen, PhD, a Post-Doctoral Researcher in the Department of Automation Science and Engineering at the University of Tampere in Tampere, Finland!
...Bio-Techne Awards Cancer Researcher $40,000 Grant
星期一, 十一月 13, 2017 - 21:58
Advanced Cell Diagnostics, a Bio-Techne Brand, completed a yearlong 'RNAscope ISH Get Hybridized' giveaway awarding Dr. Andreas Behren from the Olivia Newton-John Cancer Research (ONJCRI) Institute in Melbourne, Australia the grand prize of $40,000 grant to support his research in Cancer Immunobiology.
Several thousand researchers from around the world participated in the year-long giveaway by describing their research and its impact, as well as a potential role for RNAscope ISH.
The grant was presented at the Bio-Techne Wax Museum Party at the Society for Neuroscience 2017 Annual Meeting in Washington DC on November 13, 2017.
At the event, Dr....
5 Reasons Why the Cultrex Brand Is Essential for 3D Cell Culture
星期四, 十一月 9, 2017 - 14:56
When Bio-Techne acquired Trevigen we expanded our offering of Cultrex® Basement Membrane Extract (BME) and Cultrex® Extracellular Matrix (ECM) Proteins, strengthening our portfolio of tools for 3D cell culture. Cultrex® BME and ECM are primed to become an integral set of scaffolding reagents for cancer and regenerative medicine research, specifically through the growth of organoids and...
CAR-TCR Summit 2017
星期三, 十一月 1, 2017 - 11:21
By Janice Frias, Ph.D., Bio-Techne Scientist
The CAR-TCR Summit in Boston from September 5-8 could not have had a better venue than the Seaport World Trade Center. The space was the perfect size for a group like this. It was able to accommodate all the concurrent talks and expo, yet keep the attendees in still a rather intimate setting to encourage interaction. And a glance out the window at the Boston Harbor in between talks was a nice perk.
The summit was very timely in that the week prior, the Novartis CAR T therapy, Kymriah, received FDA approval to fight leukemia in children and young adults. This was a hot topic, sparking speculation about who is...
Stem Cells in the News - November 2017
星期一, 十月 30, 2017 - 15:16
We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.
USC News
With incidences of liver cancer steadily on the rise since 2003, it is important that we discover new routes of therapeutic options for patients. A team of...
Building Better 2D and 3D Culture Solutions - Bio-Techne and Trevigen
星期一, 十月 23, 2017 - 12:38
On September 5, 2017 Bio-Techne proudly announced its acquisition of Trevigen, Inc. For over 25 years, Trevigen has developed innovative tools for generating and analyzing physiologic cell culture models, such as organoids, tumorspheres, and stem cell-derived cellular systems. These models are being used to make critical advancements in drug discovery, toxicology, regenerative medicine, cell therapy, and cancer research. With strong brands like the Cultrex® Basement Membrane Matrix and the CometAssay® for cell damage, the Trevigen product portfolio is an important addition to Bio-Techne....
Bio-Techne Go Everywhere Travel Grant - September Recipient Selected!
星期二, 十月 17, 2017 - 09:09
September 2017 Go Everywhere with Bio-Techne Travel Grant Awarded to Medical Biologist at Linköping University!
Bio-Techne launched its Go Everywhere Travel Grant Program which awards $1000 USD (or equivalent) to 1 researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.
The recipient of the September 2017 grant is Helena Enocsson, a Medical Biologist in the Clinical and Experimental Medicine Department at Linköping University in Linköping, Sweden!
...Immunology News: Researchers Report the Identification of a New Regulatory Innate Lymphoid Cell Subset that Suppresses Innate Intestinal Inflammation
星期五, 十月 13, 2017 - 07:37
Regulatory ILCs Suppress ILC1- and ILC3-Induced Innate Intestinal Inflammation
Innate lymphoid cells (ILCs) are a recently described population of lymphocytes that play a critical role in innate immune responses and tissue remodeling. Multiple studies suggest that ILCs are particularly important for maintaining epithelial barriers and regulating immune responses at mucosal surfaces such as the lungs and intestines. Similar to T cells, ILCs consist of several subtypes that are characterized by the expression of different transcription factors and cytokines, and these correspond with the...
Stem Cells in the News - October 2017
星期五, 九月 29, 2017 - 15:44
We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.
Journal of Experimental Medicine
While Zika virus infection can be detrimental to the developing brain, it may have a therapeutic application. Researchers at the University of California - San Diego and the...
Tocris Bioscience Launches New Website
星期一, 九月 18, 2017 - 13:50
We are delighted to introduce you to the new Tocris Bioscience website. The Tocris team felt it was time to modernize the look and feel of the site, as well as add some exciting new functionality, which is outlined below. When designing the site our aim was to create an enhanced user experience and introduce new features to aid researchers in their purchasing decision. This is exemplified by our quick and easy checkout and registration process, as well as new customer profiles, live chat, customer product reviews and product comparisons.
New User Profiles
Creating new and improved customer profiles means we will be...
Bio-Techne Go Everywhere Travel Grant - August Recipient Selected!
星期二, 九月 12, 2017 - 14:22
August 2017 Go Everywhere with Bio-Techne Travel Grant Awarded to Graduate Student from the University of California Davis!
Bio-Techne launched its Go Everywhere Travel Grant Program which awards $1000 USD (or equivalent) to 1 researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.
The recipient of the August 2017 grant is Cameron Flayer, a Graduate Student Researcher in the Internal Medicine Department of the University of California, Davis!
...Stem Cells in the News - September 2017
星期三, 九月 6, 2017 - 13:49
We have captured this month's most interesting, innovative, and maybe some of the strangest examples of stem cells in the news from around the world.
NYU Langone
A significant number of blood cancers have something in common, a mutation in the TET2 gene. This gene encodes an enzyme...
Atherosclerosis Disease Progression Cell Markers
星期二, 八月 29, 2017 - 14:56
R&D Systems Cell Marker Pages: The Easiest Way to Plan Your Next Experiment
One of the challenges of moving into a new research field or expanding your current field of study is determining the best markers to identify the cells you want. R&D Systems has been providing researchers with reliable tools for defining cell populations for over 30 years. Now we’ve added new Cell Marker Tools for Atherosclerosis, Asthma, and...
A Role for VSIG-3/VISTA Signaling in Acquired Resistance to Anti-PD-1 Therapy?
星期三, 八月 23, 2017 - 09:33
Immunotherapy has revolutionized the way we treat cancer. Ground breaking studies have demonstrated that co-signaling molecules such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death 1 (PD-1) receptor, and programmed death ligand 1 (PD-L1) are an important therapeutic targets. However, these victories have been tempered by the development of acquired resistance in some cases. Why is this happening? What are the mechanisms of acquired resistance to immune checkpoint blockade?
...
R&D Systems Develops A Highly Sensitive and Specific Assay to Detect Anti-Zika Virus IgG
星期二, 八月 22, 2017 - 12:16
Zika virus (ZIKV) is a mosquito-borne, single-stranded, positive-sense RNA virus belonging to the Flaviviridae family. It is closely related to other members of the Flavivirus genus including dengue virus, West Nile virus, yellow fever virus, tick-borne encephalitis virus, and Japanese encephalitis virus. ZIKV was first isolated from a rhesus monkey in Uganda in 1947 and the first human cases were detected in the 1950s in Uganda, Tanzania, and Nigeria. Since that time, there have been significant outbreaks in Africa, Southeast Asia, and the Pacific Islands, but the...
Bio-Techne Go Everywhere Travel Grant - July Recipient Selected!
星期三, 八月 16, 2017 - 13:52
July 2017 Go Everywhere with Bio-Techne Travel Grant Awarded to PhD Student from the University of Lisbon!
Bio-Techne launched its Go Everywhere Travel Grant Program which awards $1000 USD (or equivalent) to 1 researcher each month to attend the meeting of their choice. This grant program allows the researcher to attend more targeted meetings in their field and provides funding to support both small and large scientific associations that promote discovery and collaboration.
The recipient of the July 2017 grant is Pedro Papotto, a PhD Student at the Institute of Molecular Medicine at the University of Lisbon in Portugal!
...