Mouse IGF-I/IGF-1 Biotinylated Antibody Summary
Gly33-Ala102
Accession # Q8CAR0
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Applications
Mouse IGF-I/IGF-1 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IGF-I/IGF-1
Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N- and C-terminal propeptides (1). These isoforms are differentially expressed by various tissues (1). The 7.6 kDa mature IGF-I is identical between isoforms and is generated by proteolytic removal of the N- and C-terminal regions. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively (2), and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF‑II. Circulating IGF-I is produced by hepatocytes, while local IGF-I is produced by many other tissues in which it has paracrine effects (1). IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally (3). IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism (4-7). It plays an important role in muscle regeneration and tumor progression (1, 8). IGF-I binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R (9). IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors (10).
- Philippou, A. et al. (2007) In Vivo 21:45.
- Bell, G.I. et al. (1986) Nucleic Acids Res. 14:7873.
- Guvakova, M.A. (2007) Int. J. Biochem. Cell Biol. 39:890.
- Clemmons, D.R. (2006) Curr. Opin. Pharmacol. 6:620.
- Bluher, S. et al. (2005) Best Pract. Res. Clin. Endocrinol. Metab. 19:577.
- Garcia-Segura, L.M. et al. (2006) Neuroendocrinology 84:275.
- Malemud, C.J. (2007) Clin. Chim. Acta 375:10.
- Samani, A.A. et al. (2007) Endocrine Rev. 28:20.
- LeRoith, D. and S. Yakar (2007) Nat. Clin. Pract. Endocrinol. Metab. 3:302.
- Denley, A. et al. (2005) Cytokine Growth Factor Rev. 16:421.
Product Datasheets
Citations for Mouse IGF-I/IGF-1 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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Cysteine induces longitudinal bone growth in mice by upregulating IGF-I
Authors: PHIL-DONG MOON, MIN-HO KIM, HYUN-A OH, SUN-YOUNG NAM, NA-RA HAN, HYUN-JA JEONG et al.
International Journal of Molecular Medicine
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Spatial distribution of insulin-like growth factor binding protein-2 following hypoxic-ischemic injury.
Authors: Fletcher L, Isgor E, Sprague S, Williams L, Alajajian B, Jimenez D, Digicaylioglu M
BMC Neurosci, 2013-12-21;14(0):158.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: ELISA Development (Detection) -
IGFBP-3 is a metastasis suppression gene in prostate cancer.
Authors: Mehta HH, Gao Q, Galet C
Cancer Res., 2011-06-22;71(15):5154-63.
Species: Mouse
Sample Types: Serum
Applications: ELISA Development -
Evidence of a role for insulin-like growth factor binding protein (IGFBP)-3 in metabolic regulation.
Authors: Yamada PM, Mehta HH, Hwang D
Endocrinology, 2010-10-06;151(12):5741-50.
Species: Mouse
Sample Types: Serum
Applications: ELISA Development -
Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastases.
Authors: Wang N, Fallavollita L, Nguyen L, Burnier J, Rafei M, Galipeau J, Yakar S, Brodt P
Mol. Ther., 2009-04-14;17(7):1241-9.
Species: Mouse
Sample Types: Plasma
Applications: ELISA Development -
Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model.
Authors: Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, Glode LM, Greenberg NM, Hwang D, Cohen P, Pollak MN, Agarwal R
Cancer Res., 2007-11-15;67(22):11083-91.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: ELISA Development
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Homemade ELISA, used R and D systems capture antibody and purified protein
