Mouse Lipocalin-2/NGAL Biotinylated Antibody Summary
Gln21-Asn200
Accession # P11672
Customers also Viewed
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Lipocalin-2/NGAL
Mouse Lipocalin-2 was cloned from mouse kidney cells (1). Its very high level of expression at the post-stratum uterus gave it the name uterocalin (2). Lipocalin-2 has been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis (3 - 5). Studies indicate that Lipocalin-2 binds a bacterial catecholate siderophore that is bound to a ferric ion, such as enterobactin, with a subnanomolar dissociation constant (KD = 0.41 nM) (6). The bound ferric enterobactin complex breaks down slowly in a month into dihydroxybenzoyl serine and dihydroxybenzoic acid (DHBA). It also binds to a ferric DHBA complex with much less KD values (7.9 nM) (6). Secretion of Lipocalin-2 in immune cells increases in response to stimulation of Toll-like receptor as an acute phase response to infection. As a result, it acts as a potent bacteriostatic reagent by sequestering iron (7). Moreover, Lipocalin-2 can alter the invasive and metastatic behavior of Ras-transformed breast cancer cells in vitro and in vivo by reversing the epithelial to mesenchymal transition inducing activity of Ras, through restoration of E-cadherin expression, via effects on the Ras-MAPK signaling pathway (8).
- Hraba-Renevey, S. et al. (1989) Oncogene. 4:601.
- Liu, Q. et al. (1993) Mol Reprod Dev. 46:507.
- Kjeldsen L, et al. (2000) Biochim Biophys Acta. 1482:272.
- Devireddy, L.R. et al. (2001) Science 293:829.
- Yang, M.B. et al. (2002) Mol. Cell. 10:1045.
- Goetz, D.H. et al. (2002) Mol. Cell 10:1033.
- Flo, T.H. et al. (2004) Nature 432:917.
- Hanai, J. et al. (2005) J. Biol. Chem. 280:13641.
Product Datasheets
Citations for Mouse Lipocalin-2/NGAL Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
6
Citations: Showing 1 - 6
Filter your results:
Filter by:
-
Blockade of ERK1/2 by U0126 alleviates uric acid-induced EMT and tubular cell injury in rats with hyperuricemic nephropathy
Authors: Min Tao, Yingfeng Shi, Lunxian Tang, Yi Wang, Lu Fang, Wei Jiang et al.
American Journal of Physiology-Renal Physiology
-
Highly Dynamic Transcriptional Signature of Distinct Macrophage Subsets during Sterile Inflammation, Resolution, and Tissue Repair
Authors: Tamas Varga, Rémi Mounier, Attila Horvath, Sylvain Cuvellier, Florent Dumont, Szilard Poliska et al.
The Journal of Immunology
-
Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation.
PLoS ONE, 2012-09-05;7(9):e44328.
Species: Mouse
Sample Types: Serum
Applications: Western Blot -
The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis.
Kidney Int, 2012-05-23;82(7):759-70.
Species: Mouse
Sample Types: Serum
Applications: Western Blot -
Deletion of TLR5 results in spontaneous colitis in mice.
Authors: Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT
J. Clin. Invest., 2007-12-01;117(12):3909-21.
Species: Mouse
Sample Types: Serum
Applications: Western Blot -
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection.
Authors: Vijay-Kumar M, Wu H, Jones R, Grant G, Babbin B, King TP, Kelly D, Gewirtz AT, Neish AS
Am. J. Pathol., 2006-11-01;169(5):1686-700.
Species: Mouse
Sample Types: Serum
Applications: Western Blot
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsIsotype Controls
Reconstitution Buffers
Staining Reagents
Supplemental Cell Selection Products
Supplemental ELISA Products
Reviews for Mouse Lipocalin-2/NGAL Biotinylated Antibody
There are currently no reviews for this product. Be the first to review Mouse Lipocalin-2/NGAL Biotinylated Antibody and earn rewards!
Have you used Mouse Lipocalin-2/NGAL Biotinylated Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
