Mouse VEGFR3/Flt-4 Biotinylated Antibody Summary
Tyr25-Asp770
Accession # P35917
Applications
Mouse VEGFR3/Flt-4 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: VEGFR3/Flt-4
VEGFR3 (Flt-4), together with VEGFR1 (Flt-1) and VEGFR2 (KDR/Flk-1), belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of these receptors is almost exclusively restricted to the endothelial cells. These receptors are likely to play essential roles in vasculogenesis and angiogenesis.
In adults, VEGFR3 expression is restricted to the endothelial cells of the lymphatic vessels. Mouse VEGFR3 cDNA encodes a 1363 amino acid (aa) residue precursor protein with a 24 aa residue signal peptide. Mature VEGFR3 has a 751 aa residue extracellular domain, a 22 aa residue hydrophobic transmembrane domain, and a 565 aa residue cytoplasmic domain. The polypeptide sequences of murine Flt-4 is 88% identical to the human homologue. VEGFR3 has been reported to serve as the receptors for VEGF-C and VEGF-D.
- Finnerty, H. et al. (1993) Oncogene 8:2293.
- Joukov, V. et al. (1996) EMBO J. 15:290.
- Achen, M. et al. (1998) Proc. Natl. Acad. Sci. USA 95:548.
Product Datasheets
Citations for Mouse VEGFR3/Flt-4 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/?-Catenin Signaling
Authors: B Cha, X Geng, MR Mahamud, JY Zhang, L Chen, W Kim, EH Jho, Y Kim, D Choi, JB Dixon, H Chen, YK Hong, L Olson, TH Kim, BJ Merrill, MJ Davis, RS Srinivasan
Cell Rep, 2018-10-16;25(3):571-584.e5.
Species: Mouse
Sample Types: Whole Tissue
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Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner
Authors: HB Song, SY Park, JH Ko, JW Park, CH Yoon, DH Kim, JH Kim, MK Kim, RH Lee, DJ Prockop, JY Oh
Mol. Ther., 2017-10-05;26(1):162-172.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1.
Authors: Gale NW, Prevo R, Espinosa J, Ferguson DJ, Dominguez MG, Yancopoulos GD, Thurston G, Jackson DG
Mol. Cell. Biol., 2006-11-13;27(2):595-604.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis
Authors: Christopher J. Benwell, Robert T. Johnson, James A.G.E. Taylor, Christopher A. Price, Stephen D. Robinson
Cancer Research Communications
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