(S)-AMPA
Chemical Name: (S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Purity: ≥99%
Biological Activity
(S)-AMPA is an active enantiomer of AMPA (EC50 = 3.5 μM).NPEC-caged-(S)-AMPA, Inactive Enantiomer and Racemate also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships.
Falch et al.
J.Med.Chem., 1998;41:2513 -
Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid.
Hansen et al.
J.Med.Chem., 1983;26:901 -
Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors.
Lauridsen et al.
J.Med.Chem., 1985;28:668
Product Datasheets
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Citations for (S)-AMPA
The citations listed below are publications that use Tocris products. Selected citations for (S)-AMPA include:
13 Citations: Showing 1 - 10
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Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex.
Authors: Gasull-Camôs
Neuropharmacology ;139:41
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Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
Authors: Wagner Et al.
Cell Rep 2019;28:11
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The Retromer Supports AMPA Receptor Trafficking During LTP.
Authors: Temkin Et al.
Neuron 2017;94:74
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Kynurenic Acid Induces Impairment of Oligodendrocyte Viability: On the Role of Glutamatergic Mechanisms.
Authors: Langner Et al.
Neurochem Res 2017;42:838
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Involvement of AMPA Receptor and Its Flip and Flop Isoforms in Retinal Ganglion Cell Death Following Oxygen/Glucose Deprivation.
Authors: Park Et al.
Invest Ophthalmol Vis Sci 2016;57:508
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Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
Authors: Bell Et al.
PLoS One 2015;6:7066
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Membrane potential measurements of isolated neurons using a voltage-sensitive dye.
Authors: Fairless Et al.
PLoS One 2013;8:e58260
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Physiological release of endogenous tau is stimulated by neuronal activity.
Authors: Pooler Et al.
J Neurosci 2013;14:389
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Overexpression of calcium-permeable glutamate receptors in glioblastoma derived brain tumor initiating cells.
Authors: Oh Et al.
EMBO Rep 2012;7:e47846
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Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
Authors: Lussier Et al.
Proc Natl Acad Sci U S A 2011;31:3077
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Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
Authors: Jackson Et al.
PLoS One 2010;5:e11962
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Hypoxic injury of isolated axons is independent of ionotropic glutamate receptors.
Authors: Underhill
Neurobiol Dis 2007;25:284
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Properties of GluR3 receptors tagged with GFP at the amino or carboxyl terminus.
Authors: Limon Et al.
Neuroreport 2007;104:15526
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