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Selinexor

Catalog #: 7760 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7760/10
7760/50
Selinexor | CAS No. 1393477-72-9 | Antiviral Compounds
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Description: Selective exportin 1 (XPO1/CRM1) inhibitor

Chemical Name: (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide

Purity: ≥98%

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Biological Activity

Selinexor is an inhibitor of the exportin 1 (XPO1/CRM1) nuclear exporter. Shows selectivity for TNBC over ER-positive breast cancer cell lines (IC50 values are 11-550 nM and >1000 nM, respectively), and reduces growth of xenografts. Inhibits growth of thyroid cancer cell lines (IC50 = 150-500 nM), potentiates the anti-tumor effects of Olaparib (Cat. No. 7579) in ovarian cancer and breast cancer. Also a potent inhibitor of SARS-CoV-2 replication in vitro (EC50 = 10 nM) and downregulates the production of pro-inflammatory cytokines including TNF-α and IL-6.

Technical Data

M.Wt:
443.31
Formula:
C17H11F6N7O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1393477-72-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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