Autoimmune Regulator/AIRE: Products

Autoimmune Regulator (AIRE) is required for the development of T cell tolerance. It regulates the expression of self-antigens by thymic epithelial cells, and mutations in AIRE are causative of the autoimmune disorder, APECED. AIRE regulates gene transcription through interactions with DNA, histone H3, and the nuclear matrix. It contains one HSD domain, a nuclear localization sequence, one SAND domain, and two PHD zinc finger domains.