HTRA2/Omi: Products

HTRA2/Omi is the mammalian homolog of the bacterial high temperature requirement protein (HTRA). HTRA2/Omi is a homotrimeric serine protease that localizes to the mitochondria and is processed to expose an N-terminal reaper-like motif similar to SMAC/Diablo. HTRA2/Omi is released from the mitochondria in response to apoptotic insult and can interact with the BIR2 or BIR3 domains of XIAP to relieve caspase-IAP inhibition.