"plc" has 10 results in Resources.

Overview of Platelet Signaling Through GP Adhesion Proteins The GP family of glycoproteins mediate the initial adhesion of platelets to the endothelium. They interact with several ECM molecules at sites of endothelial damage and also with circulating soluble factors. GP adhesion proteins associate in cis with other platelet surface molecules and initiate intracellular signaling that leads to the...

Overview of Platelet Signaling Through Activated Integrin α2bβ3 Integrin heterodimers are expressed on resting platelets in inactive conformations. They become activated by the recruitment of a RIAM-Rap1 containing protein complex in response to signaling from GP glycoproteins, GPCRs, and integrins themselves. Of the various integrin heterodimers expressed on platelets, Integrin α2bβ3 plays a...

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Analyte DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA Development Systems (Phospho) Quantikine® ELISA Kits Akt (S473)   DYC887B   Akt (T308)       AMPK alpha1 (T174) DYC3197 DYC3528   AMPK alpha2 (T172)       beta-Catenin DYC1329     Chk2...

Human Phospho-Kinase Antibody Array Ordering Information Introduction Analyzing the phosphorylation profiles of kinases and their protein substrates is essential for understanding how cells recognize and respond to changes in their environment. The Human Phospho-Kinase Array (Catalog # ARY003B) is a rapid, sensitive, and economical tool to simultaneously detect the relative site-specific...

Analyte Phospho-Specific Antibodies Affinity Purified Polyclonal Antibodies (Total) Monoclonal Antibodies (Total) Labeled Antibodies (Total) Akt (S473) AF887 (S473) AF2055 MAB2055   Akt (T308)   AF2055 MAB2055   AMPK alpha1 (T174)   AF3197 MAB3197   AMPK alpha2...

Featured Literature Chemokine Superfamily Poster View Poster   Overview of Chemokine Signaling Pathways Chemokines are a large family of small (typically 8-14 kDa), chemoattractant proteins that play a central role in controlling leukocyte migration during development, homeostasis, and inflammation. Following secretion, soluble chemokines or those localized to...

The mammalian Fibroblast Growth Factor (FGF) superfamily consists of eighteen secreted proteins (FGF-1 – FGF-10 and FGF-16 – FGF-23) and four intracellular FGFs (FGF-11 – FGF-14), known as FGF homologous factors. The secreted FGFs belong to one of six subfamilies (FGF-1, FGF-4, FGF-7, FGF-8, FGF-9, and FGF-19) based on sequence homology, biological functions, and evolutionary...

Greta Wegner, Erin Eleria, Jackie Ernst, & Amy James THE PROBLEM: Time-consuming Western blots Assessing phosphorylation changes in multiple interrelated pathways Performing pharmacological screens in a timely manner Identifying off-target pharmacological effects THE SOLUTION: Proteome Profiler™ Phospho-Antibody Arrays Easier to perform than a Western blot Uncover new...

First Published in R&D Systems' 2005 Catalog Contents Immunological Synapse Formation Granule Contents and Their Functions Conclusion References Cytotoxic T lymphocytes (CTLs) and Natural Killer (NK) cells play critical roles in the immune response to viruses and cellular transformation. This results from their ability to recognize and initiate apoptosis in the affected cells. CTLs...